Compound of Interest - "Hit" Identified from a High-Throughput Screening Study

 

Control "hit" compound of interest.

Undergraduate researchers in the D'Antonio Laboratory will begin their research by re-confirming enzyme - inhibitor kinetics by using an identified hit compound, as shown in the image. This compound will act as a control. Once trained on establishing the IC50 or Ki value for this compound by exposing it to Trypanosoma cruzi glucokinase during its enzymatic reaction, the students will be ready to perform further testing with the compound screening library. The compound screening library accounts for the majority of the funds needed for this online fundraiser.