May 23, 2023
The purpose of my research program since 2013 has been to identify novel chemical compounds and scaffolds that inhibit important enzyme targets of pathogenic microorganisms. It has also been to thoroughly prepare my undergraduate research students to move forward into notable programs after graduation from the University of South Carolina Beaufort.
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The etiological agent for Chagas' disease is the protozoan parasite Trypanosoma cruzi, which affects 6 - 7 million people primarily in Latin America. The chronic stage of infection causes cardiomyopathy and the enlargement of other organs resulting in disease burden and death. There is an urgent need to replace the clinical therapeutics (benznidazole & nifurtimox) and this proposal focuses on a compound screen to observe a hit expansion with the target T. cruzi glucokinase.
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