Project Results

Thanks to the support we received from our friends, MAX BioPharma was able to conduct a study to explore the effects of oxysterol on hair growth in a very humane mouse model.  Our observations from this study are significant and crucial in our ability to decide what additional studies will be needed to further pursue the use of oxysterols in hair growth indications.  We hope to have future observations to share about this topic in the near future.  Cheers.

About This Project

Hair loss can affect both men and women, often leaving a negative impact on the affected person’s life. Stem cells associated with hair follicles drive normal hair growth but lie dormant in bald spots. We propose to test topical applications of Oxy133, a drug candidate that can safely increase Hedgehog signaling, in a mouse model of hair growth. We hypothesize that dormant hair stem cells will be stimulated by Oxy133, resulting in increased hair growth in mice and (eventual) human testing.

Ask the Scientists

What is the context of this research?

Available drug treatments for hair loss (Propecia, Avodart or Rogaine) are modestly effective at best and often plagued by unpleasant side effects. In male pattern baldness, hormonal and other factors lead to a shortened growth (anagen) phase of the hair follicle, resulting in deactivated hair stem cells and diminished hair growth. To regrow lost hair, it may be possible to reactivate dormant hair stem cells by stimulating their cellular signaling. The Hedgehog signaling pathway provides a cellular signal crucial for hair growth that can trigger hair follicles to reenter an active growth phase. At MAX BioPharma, a startup company based in Santa Monica, California, we have developed Oxy133, a drug candidate that can stimulate Hedgehog signaling through a safe ‘allosteric’ mechanism.*

What is the significance of this project?

It is estimated that 40 million Americans suffer from hair loss.* Most hair loss is actually caused by a lack of hair regrowth rather than the increased shedding of hair. Available treatment options typically work far better to prevent further hair loss than to regrow lost hair. This project will address the question whether Oxy133 can safely stimulate hair stem cells in mice and trigger increased hair regrowth. In principle, this application could translate into a hair growth treatment for humans, as Hedgehog signaling functions similarly across species.* Successful experimental outcomes would then allow us to partner with pharmaceutical and cosmetic companies, as well as investors, to further develop the drug and advance to human testing and eventual commercialization.

What are the goals of the project?

The immediate goal of the project is to test the ability of Oxy133, a sterol based activator of Hedgehog signaling, to enhance hair growth in mice through topical application of the compound, a simple but effective model of hair regrowth. We believe that Oxy133 is highly suited for dermatological applications due its high solubility in skin oil. If successful, this pilot study will provide data that can be presented to potential industry partners and investors who will help us develop the technology for commercialization. The long term goal of this project is to offer a new, safe and effective treatment option to people suffering from hair loss.