Hair loss can affect both men and women, often leaving a negative impact on the affected person’s life. Stem cells associated with hair follicles drive normal hair growth but lie dormant in bald spots. We propose to test topical applications of Oxy133, a drug candidate that can safely increase Hedgehog signaling, in a mouse model of hair growth. We hypothesize that dormant hair stem cells will be stimulated by Oxy133, resulting in increased hair growth in mice and (eventual) human testing.