Jan 15, 2016
Our research article titled "A DNA-binding molecule targeting the adaptive hypoxic response in multiple myeloma has potent in vivo and in vitro anti-tumor effects" was just accepted for publication! This work represents about 3-4 years of scientific effort and will appear in a very well respected journal (Molecular Cancer Research) in a few months from now.
Multiple myeloma (MM) is a cancer of the bone marrow made up of plasma cells (a type of antibody-producing white blood cells). Low oxygen levels (called hypoxia) in the bone marrow increases gene expression in MM tumor cells as part of an adaptive survival response. We are targeting this hypoxic response with an experimental drug that blocks expression of these genes to ask if this molecule kills MM in the bone marrow. This is a novel approach to treat MM, an incurable disease.
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