Homeworld Collective
Homeworld Collective is dedicated to nurturing the growth of climate biotech by fostering community, building knowledge, and directly supporting early stage research. Together we can work toward a healthy biosphere and thriving human society.
Projects
27
Generalizable Computational Pipeline for Engineering Ultrastable Variants of Carbonic Anhydrase
AI-driven protein design is undergoing a transformation, driven by recent breakthroughs such as AlphaFold...
Immobilisation of carbonic anhydrase for more efficient direct air capture
Direct air capture (DAC) is a promising pathway for atmospheric CO2 removal. Biocatalysts like carbonic...
100%
funded
$61,050
goal
1
lab notes
Designing ultrastable carbonic anhydrase with deep generative models and high-throughput assays
To minimize the impact of CO2 emissions on life on earth, we need technologies for carbon capture exceeding...
Engineered nutritional yeasts as versatile and delicious cell-based meals
Towards reducing manufacturing costs for meat alternatives while increasing their palatability, we aim to...
Efficient biological upcycling of polyethylene terephthalate (PET) into high-value compounds
Polyethylene terephthalate (PET) can be efficiently hydrolyzed by enzymes only at high temperatures (~70...
Generative AI-Based Design of Novel Silicase Enzymes for Carbon-Sequestering Agriculture
Enhanced weathering is a scalable strategy for sequestering atmospheric CO2 and increasing crop productivity...
Engineering Carbonic Anhydrase for Efficient Immobilization and Mass Transfer for CO2 Removal
Technologies that remove carbon dioxide from emissions and air are urgently needed to mitigate the effects...
Catalyzing biofuel production – a proof of concept and screening platform for designing proteins for organic solvents
Using enzymes in environments other than water has enormous bioengineering potential, but a major roadblock...
100%
funded
$137,500
goal
1
lab notes
CALORIE-DAC. Carbonic Anhydrase For LOw RegeneratIon Energy Direct Air Capture
We investigate technoeconomics and aspirational CA targets for CA-enhanced KOH/K2CO2 DAC processes with...
100%
funded
$88,103
goal
1
lab notes
De novo protein design for photochemical water oxidation and renewable solar fuels
Photosynthesis sustains the biosphere, but it operates with low overall efficiency. By designing brand new...
Improving the CO2 Capture Efficiency of Plants Through Enzyme Engineering
Plants capture CO2 from air to build sugars, which allows them to grow through a process called photosynthesis...
Filtration Systems from Renewable Silk Materials
The goal of this project is to design filtration technologies using sustainability, energy costs and environmental...
Improve the CO2 Uptake and H2O Retention under High Light and Temperature Conditions.
Plants need efficient CO2 uptake to enhance photosynthesis (PS). However, high temperatures prompt stomatal...
Scaling the Bioeconomy: Debottlenecking Biomanufacturing with Enhanced P450s
Delivering best-in-class enzymes for biomanufacturing.
Designing new enzymes for sustainable fertilizer
Agriculture relies on phosphorous (P) fertilizer, which generates algae blooms and significant GHG emissions...
Generative Design of Programmable Metal-Binding Proteins for Bioremediation
The mining of heavy metals accounts for about 10% of global greenhouse gas emissions. Moreover, exposure...
Which methanotrophs drive methane degradation in the phyllosphere of trees?
Methane (CH4) accounts for ~30% of climate forcing and atmospheric methane removal (AMR) has significant...
Worms at Work: Scoping Natural Carbon Sequestration at Scale
For centuries, scientists noted earthworms' exploits as ecosystem engineers. Recent research shows the feasibility...
Lithogardens: lithoautotrophy-powered microbial communities for improved carbon capture with enhanced rock weathering
By 2050, the process of enhanced rock weathering can be capturing 0.3 Gt CO2/yr in the US alone [1], but...
Highly-sensitive, real-time enzyme methane oxidation rate measurements using an electrochemical assay
A low-cost, rapid, and highly sensitive assay is needed to measure methane gas oxidation rates by methane...
Coupling of microbial carbon capture and utilization (microCCU) and direct air capture (DAC)
Reducing atmospheric CO2 is critical to mitigating climate change, and negative emission technologies (NETs...
Profiling in vivo pMMO activity and lipid order in methanotrophs using designed fluorescent biosensors
Remediating methane requires the uniquely potent enzyme methane monooxygenase (MMO). All attempts to express...
Enhancing Carbon Sequestration By Improving Photosynthetic Efficiency
Enhancing photosynthesis can help mitigate greenhouse gases, but plants and algae use only visible light...
Continuous siderophore-mediated olivine weathering
We propose that bacterial siderophores could accelerate mineral weathering reactors as an additive. Our...
Compound I-based design of methane monooxygenases
Building upon previous work showing that compound I from cytochome P450 monooxygenase can oxidize methane...
Biomapping of Tree-based Atmospheric Methane Removal (TAMR) for Technological Development
Tree surfaces can be an effective approach for AMR, although foundational information is lacking. Here...
Low Cost Sensors for Soil Methane Uptake
Affordable methane sensors capable of measuring concentrations around atmospheric level are a crucial tool...
