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Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial and macrophage in vivo responses relevant to human Crohn’s disease (Part1)
Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial and macrophage in vivo responses relevant to human Crohn’s disease (Part1)We got a lot of data recent...
Visualizing and quantifying gut mucus. (Last lab note for publics)
On our previous lab note, we showed the visualization and quantification of acidic lysosomes in gut cells. Those lysosomes are mostly produced in innate immune cells such as macrophages and neu...
Visualizing and quantifying lysosome in fish gut
Today we are reporting results for our first milestone: Establish live zebrafish quantifiable staining matrices with lysosomal pH. Our previous lab note showed that we are able to mimic acute, ...
Result 1: Could we induce acute and chronic intestinal injury by using a zebrafish model?
Result 1: Could we induce acute and chronic intestinal injury by using a zebrafish model? There are three main disease stages in an inflammatory bowel disease (IBD): acute infection/injury, chro...
Why do we need better animal model for studying inflammatory bowel disease (IBD)? Why zebrafish?
Why do we need better animal model for studying inflammatory bowel disease (IBD)? Why zebrafish?The current clinical phenotypes of IBD are mainly based on measuring the chronic and accumulative dam...