Inflammatory bowel disease (IBD) is a chronic intestinal disease that affects 3 million Americans. Animal models provide significant contributions to dissect the mechanism and develop novel therapeutic strategies. Large-scale and high speed live imaging of intestine can be uniquely performed on zebrafish. We propose to build a novel fish colitis model for studying host-pathogen interaction and drug screening in real-time. With your help, we would love to accomplish these work with our students.