Apr 02, 2019
For our experiments, we use human T-cells. In order to maintain the cells, they regularly need new nutrition and have to be split as they do not grow when they reside in a too high density of cells. In this video, you can see how we do this. All credits for our research assistant Sarah, who recorded this movie.
Our immune T-cells are a type of white blood cell that are crucial to recognise and attack infections and cancerous cells. For this reason, T-cells are important drug targets in vaccines and cancer immunotherapies. A drug currently in pre-clinical development is showing promising results in boosting a key regulator in T-cell functions 500-fold, but how this happens remains a mystery. We hypothesise that the drug increases the active state of the T-cell regulator by inducing a structural change.
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