sbradley4

After studying molecular and cellular biochemistry at the University of Oxford, Dr. Samuel Bradley took up a PhD position in the Synthetic Biology Tools for Yeast group under Dr Michael Krogh Jensen at the NNF Centre for Biosustainability (Technical University of Denmark). During his PhD research, Dr Bradley developed a suite of S. cerevisiae strains capable of producing unnatural, halogenated variants of medicinal phytochemicals. Following the realization that many metabolic pathway engineering projects are limited by just one or two poorly performing enzymes, his research interests focused on how protein engineering techniques can be more integrated into the metabolic engineering workflow. In particular, how powerful new computational techniques that aid protein engineering, such as Alpha Fold, ESM, ProteinMPNN and RFDiffusion, can be combined with smart library design for rapid enzyme improvement. After being awarded his PhD in 2024, Dr Bradley took up a post-doctoral researcher position in the new Computational Protein Engineering group, led by Dr Carlos Acevedo-Rocha, at the Technical University of Denmark, where he is involved in a) developing a platform, ProteusAI, to allow biologists without technical computing knowledge to deploy machine learning models developed for protein engineering, and b) developing high-throughput methods for generating protein variant libraries for training machine learning algorithms.

February 2025