How do APS antibodies induce blood clotting?

Apr 18, 2022

How do APS antibodies induce blood clotting? 
While there is still debate on the actual mechanism that results in blood clotting in patients with APS, it is agreed that the binding of APS antibodies to cell membrane-bound Beta 2-Glycoprotein 1 on platelets, neutrophils and endothelial cells, triggeres intracellular events resulting in release of factors that trigger inflammation and and blood clotting

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About This Project

Can peptides stop recurrent miscarriage in women with autoimmune Anti-Phospholipid Syndrome?

Ariel University

Anti-Phospholipid Syndrome (APS) is an autoimmune disease in which certain antibodies cause blood clotting. These antibodies are an important cause of spontaneous miscarriage in women aged 20-50 years. There is no effective treatment for APS. Our project will test whether small peptides we have discovered, can block the activity of these antibodies. Positive results from these experiments will support further development of the peptides as a new therapy for APS.