Each year in the U.S. 23,000 people die as a direct result of antibiotic resistant infections. I hypothesize that by combining classical antibiotics, quorum sensing, and virulence inhibitors we can increase the virulence of multidrug resistant Pseudomonas aeriginosa. The results of this study simulate the evolution of multidrug resistant bacteria predicting the worst case scenarios, so we can be better prepared to fight these infections in the future.