The TDP-43 protein is involved in amyotrophic lateral sclerosis (ALS) and in frontotemporal dementia (FTLD). Furthermore, TDP-43 pathology has been associated with Alzheimer's and Parkinson’s diseases (Neuman M, Int J Mol Sci, 2009). It is becoming increasingly necessary to investigate the normal and pathological functions of this protein, whose purification is difficult to achieve as none has succeeded yet, but my preliminary results indicate that this is indeed possible.