Long-range biosensing is now possible: engineered microbes can be read from ~90 m by hyperspectral cameras. But the reporter signal is weak, buried in natural backgrounds (soil, leaves, water), and few molecules have measured spectra. HyperMix is an open-source, physics-informed deep-learning toolkit that jointly detects and unmixes engineered reporters in noisy remote cubes — with an open simulator, dataset and benchmark. MIT-licensed, built on clinical OCT methods.