MINDS: Matrescent Integration via Neuroplasticity, Dyads, and Psilocybin is a novel framework that rethinks postpartum care. Psilocybin may be an opportunity to harness neuroplasticity for integration and growth rather than a risk for depression and anxiety. We hypothesize that psilocybin-assisted interventions during the postpartum period may improve the mother-baby dyad by enhancing maternal identity integration, sensitive attunement, and bonding.