Results!
We've published our results and you can see the full paper from this link: http://physreports.physiology.org/content/4/19/e12992#T1 The PDF is also attached to this lab note below. We thank you for your support of our work.
Included below is condensed version of the Summary, Analysis, and Future Directions.
Regards,
Linda Summary
In a validation cohort, we sequenced exons from a prioritized panel of 40 genes for their associations with postexercise hypotension among obese African American and Caucasian adults with hypertension. We found that renal variants exhibited associations with postexercise hypotension after vigorous intensity, aerobic exercise but not moderate intensity, aerobic exercise among African Americans only. Renal variants should be explored further with a multi-level "omics" approach for associations with postexercise hypotension among a large, ethnically diverse sample of adults with hypertension.
Analysis
In a replication cohort using high-throughput exon sequencing, we found that renal genes from our prior work once again exhibited exercise intensity dependent associations with the ambulatory BP response to acute bouts of aerobic exercise. Our findings are preliminary and are limited by a small sample size, therefore, they should be interpreted with caution. Nonetheless they are exciting because they add new and novel information to the exercise genomic literature regarding the immediate antihypertensive effects of exercise.
Future Directions
Future work should utilize a multi-level "omics" approach involving a focused inquiry of genes related to renal function and other BP regulatory functions and their transcript and proteomic targets among a large, ethnically diverse sample of adults with hypertension to better inform clinical decision making regarding the nuances of the prescription of exercise as antihypertensive lifestyle therapy.
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