Morgan Q. Goulding

Morgan Q. Goulding

Apr 01, 2022

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1

Serendipity

What began as a bioweapon engineering project mutated into a basic investigation of the snail's conditional urge to make babies. A method was found - actually it was already known, but it was confirmed and explored - to strongly suppress that urge, while still keeping the animals happy and well-fed. We still don't know why it works, but it works pretty well (~70-80%) and it's much more affordable and eco-friendly than the original bioweapon candidate. The next practical challenge for schisto snail control must be to engineer a very efficient, very affordable baited TRAP that can be deployed by the millions, loaded with reproduction-inhibiting snail chow. This is the penultimate lab note from this project. The ultimate lab note, God willing, is going to announce the acceptance of a manuscript for publication in some humble scientific journal.

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About This Project

Schistosomiasis is a disease transmitted by snails, responsible for chronic illness of many millions of the world's poorest people, mainly in Africa. This project tests the efficacy of RNAi, a targeted genetic weapon, to kill the snails and thus curtail the spread of the disease. RNAi acts only on specific gene sequences, making it environmentally benign and preventing the evolution of resistance in snail populations. Importantly, this snail-killing material would be very cheap to produce.

Blast off!

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