Lingrui Zhang

Lingrui Zhang

Dec 29, 2024

Group 6 Copy 2
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    About This Project

    CRISPR Prime Editing (PE)-mediated gene integration holds promise for treating genetic diseases and enhancing crops but faces challenges in efficiency, payload capacity, and genetic baggage. This project engineers integrases to boost integration efficiency and capacity, enabling larger genetic manipulation. By designing orthogonal circuitry to autonomously exclude unwanted vector elements, we achieve clean, exclusive integration for impactful applications in medicine and agriculture.