Leishmaniasis is an intracellular parasitic disease caused by Leishmania, that causes up to one million new cases annually and has an annual mortality rate of 65000 people. We hypothesize that we can genetically engineer a bacterium to detect the presence of Leishmania-infected macrophages using a nitric oxide sensor, and in response, express iron chelating agents (to compete with Leishmania for iron) and consequently eliminate them from the affected cells using hydrolytic enzymes.