Duchenne muscular dystrophy (DMD) is a fatal childhood genetic disorder with no cure. It is caused by the body-wide absence of a muscle protein called dystrophin. Besides severe muscle wasting; the loss of dystrophin in the brain is linked to intellectual disability and psychiatric syndromes. How? What does dystrophin do in the brain? We will investigate to help develop whole body treatments and improve the quality of life for those living with DMD.