Six years after COVID-19, the threat from emerging and re-emerging viruses remains. We need antiviral strategies that viruses cannot easily escape.

Therapeutic interfering particles (TIPs) are engineered virus variants that disrupt virus growth while triggering protective immunity. We hypothesize that next-generation TIPs can suppress viral replication in ways that are more resistant to viral escape than existing antiviral strategies. Our project will start work to test this hypothesis.